Immunopathogenesis of lymphatic filarial disease
Identifieur interne : 004938 ( Main/Exploration ); précédent : 004937; suivant : 004939Immunopathogenesis of lymphatic filarial disease
Auteurs : Subash Babu [Inde] ; Thomas B. Nutman [États-Unis]Source :
- Seminars in immunopathology : (Print) [ 1863-2297 ] ; 2012.
Descripteurs français
- KwdFr :
- MESH :
- diagnostic : Filariose lymphatique.
- immunologie : Filariose lymphatique.
- étiologie : Lymphoedème.
- Pascal (Inist)
- Wicri :
- topic : Immunologie.
English descriptors
- KwdEn :
- Adaptive Immunity, Anatomic pathology, Animals, Cytokine, Effusion, Elephantiasis, Filarial (complications), Elephantiasis, Filarial (diagnosis), Elephantiasis, Filarial (immunology), Filariosis, Humans, Hydrocele, Immunity, Immunity, Innate, Immunology, Immunopathology, Lymphatic, Lymphatic system, Lymphedema, Lymphedema (etiology).
- MESH :
- complications : Elephantiasis, Filarial.
- diagnosis : Elephantiasis, Filarial.
- etiology : Lymphedema.
- immunology : Elephantiasis, Filarial.
- Adaptive Immunity, Animals, Humans, Immunity, Innate.
Abstract
Although two thirds of the 120 million people infected with lymph-dwelling filarial parasites have subclinical infections, ∼40 million have lymphedema and/or other pathologic manifestations including hydroceles (and other forms of urogenital disease), episodic adenolymphangitis, tropical pulmonary eosinophilia, lymphedema, and (in its most severe form) elephantiasis. Adult filarial worms reside in the lymphatics and lymph nodes and induce changes that result in dilatation of lymphatics and thickening of the lymphatic vessel walls. Progressive lymphatic damage and pathology results from the summation of the effect of tissue alterations induced by both living and nonliving adult parasites, the host inflammatory response to the parasites and their secreted antigens, the host inflammatory response to the endosymbiont Wolbachia, and those seen as a consequence of secondary bacterial or fungal infections. Inflammatory damage induced by filarial parasites appears to be multifactorial, with endogenous parasite products, Wolbachia, and host immunity all playing important roles. This review will initially examine the prototypical immune responses engendered by the parasite and delineate the regulatory mechanisms elicited to prevent immune-mediated pathology. This will be followed by a discussion of the proposed mechanisms underlying pathogenesis, with the central theme being that pathogenesis is a two-step process-the first initiated by the parasite and host innate immune system and the second propagated mainly by the host's adaptive immune system and by other factors (including secondary infections).
Url:
Affiliations:
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Le document en format XML
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Nutman</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases</s1><s2>Bethesda, MD 20892-0425</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Seminars in immunopathology : (Print)</title><title level="j" type="abbreviated">Semin. immunopathol. : (Print)</title><idno type="ISSN">1863-2297</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Seminars in immunopathology : (Print)</title><title level="j" type="abbreviated">Semin. immunopathol. : (Print)</title><idno type="ISSN">1863-2297</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptive Immunity</term><term>Anatomic pathology</term><term>Animals</term><term>Cytokine</term><term>Effusion</term><term>Elephantiasis, Filarial (complications)</term><term>Elephantiasis, Filarial (diagnosis)</term><term>Elephantiasis, Filarial (immunology)</term><term>Filariosis</term><term>Humans</term><term>Hydrocele</term><term>Immunity</term><term>Immunity, Innate</term><term>Immunology</term><term>Immunopathology</term><term>Lymphatic</term><term>Lymphatic system</term><term>Lymphedema</term><term>Lymphedema (etiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Filariose lymphatique ()</term><term>Filariose lymphatique (diagnostic)</term><term>Filariose lymphatique (immunologie)</term><term>Humains</term><term>Immunité acquise</term><term>Immunité innée</term><term>Lymphoedème (étiologie)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adaptive Immunity</term><term>Animals</term><term>Humans</term><term>Immunity, Innate</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Animaux</term><term>Filariose</term><term>Filariose lymphatique</term><term>Humains</term><term>Immunité acquise</term><term>Immunité innée</term><term>Lymphoedème</term><term>Hydrocèle</term><term>Lymphatique</term><term>Système lymphatique</term><term>Anatomopathologie</term><term>Cytokine</term><term>Immunité</term><term>Immunologie</term><term>Immunopathologie</term><term>Epanchement</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Immunologie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although two thirds of the 120 million people infected with lymph-dwelling filarial parasites have subclinical infections, ∼40 million have lymphedema and/or other pathologic manifestations including hydroceles (and other forms of urogenital disease), episodic adenolymphangitis, tropical pulmonary eosinophilia, lymphedema, and (in its most severe form) elephantiasis. Adult filarial worms reside in the lymphatics and lymph nodes and induce changes that result in dilatation of lymphatics and thickening of the lymphatic vessel walls. Progressive lymphatic damage and pathology results from the summation of the effect of tissue alterations induced by both living and nonliving adult parasites, the host inflammatory response to the parasites and their secreted antigens, the host inflammatory response to the endosymbiont Wolbachia, and those seen as a consequence of secondary bacterial or fungal infections. Inflammatory damage induced by filarial parasites appears to be multifactorial, with endogenous parasite products, Wolbachia, and host immunity all playing important roles. This review will initially examine the prototypical immune responses engendered by the parasite and delineate the regulatory mechanisms elicited to prevent immune-mediated pathology. This will be followed by a discussion of the proposed mechanisms underlying pathogenesis, with the central theme being that pathogenesis is a two-step process-the first initiated by the parasite and host innate immune system and the second propagated mainly by the host's adaptive immune system and by other factors (including secondary infections).</div></front></TEI><affiliations><list><country><li>Inde</li><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><country name="Inde"><noRegion><name sortKey="Babu, Subash" sort="Babu, Subash" uniqKey="Babu S" first="Subash" last="Babu">Subash Babu</name></noRegion></country><country name="États-Unis"><region name="Maryland"><name sortKey="Nutman, Thomas B" sort="Nutman, Thomas B" uniqKey="Nutman T" first="Thomas B." last="Nutman">Thomas B. Nutman</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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